U.S.-listed Chinese companies traded mostly lower on Wednesday, with seven of all top 10 stocks by weight in the S&P U.S. Listed China 50 index ending the day on a downbeat note.

Shares of Yum China Holdings, Inc. slumped 12.88 percent to close at 37.00 U.S. dollars apiece, the biggest laggard among the 10 stocks. Meanwhile, stocks of Chinese bio-pharmaceutical company BeiGene, Ltd., the biggest advancer, surged 5.95 percent in market closing.

Shares of Chinese e-commerce giant Alibaba rose 1.06 percent to close at 181.45 U.S. dollars apiece.

As of Tuesday, the S&P U.S. Listed China 50 index stood at 3,086.93, marking a 0.83-percent increase for the month-to-date returns and a 0.13-percent loss for the year-to-date returns.

U.S. stocks closed lower on Wednesday as investors digested a statement after the conclusion of Federal Reserve's two-day meeting in the afternoon.

The Dow Jones Industrial Average fell 174.07 points, or 0.72 percent, to 23,924.98. The S&P 500 decreased 19.13 points, or 0.72 percent, to 2,635.67. The Nasdaq Composite Index decreased 29.81 points, or 0.42 percent, to 7,100.90.