U.S. stocks closed mixed on Thursday as investors digested a batch of corporate earnings reports as well as key economic data.

The Dow Jones Industrial Average increased 112.97 points, or 0.44 percent, to 25,527.07. The S&P 500 fell 8.63 points, or 0.30 percent, to 2,837.44. The Nasdaq Composite Index fell 80.05 points, or 1.01 percent, to 7,852.19.

Facebook's shares plunged nearly 19 percent on Thursday after the company missed projections on revenue and global daily active users for the second quarter. The social media giant posted revenue of 13.23 billion U.S. dollars and 1.47 billion global daily active users.

In addition, the company advised at a call with analysts that it expected its revenue growth rates to be lower than the previous year.

Facebook's earnings per share, however, stood at 1.74 dollars, topping Wall Street estimates.

The shares of Qualcomm and Advanced Micro Devices rose 7 percent and 14.3 percent after both company posted stronger-than-forecast earnings per share and revenue.

Comcast reported mixed quarterly results, beating Wall Street estimates on earnings but falling short on revenue.

On the economic front, in the week ending July 21, the advance figure for seasonally adjusted initial claims was 217,000, an increase of 9,000 from the previous week's revised level, according to the Labor Department on Thursday. The previous week's level was revised up by 1,000 from 207,000 to 208,000.

The four-week moving average was 218,000, a decrease of 2,750 from the previous week's revised average. The previous week's average was revised up by 250 from 220,500 to 220,750, said the department.